Manchester United host Manchester City at Old Trafford on Sunday, September 13, 2026, kickoff 15:30 UTC, the first Manchester derby of the 2026-27 Premier League season. ESPN's head-to-head shows City winning both 2025-26 league meetings, 2-0 and 3-0.

Atletico Madrid host Manchester United in the Champions League league phase, Matchday 2, at Estadio Metropolitano in Madrid on Tuesday, October 13, 2026, kickoff 19:00 UTC (9:00 PM local (UTC+2)).

Como 1907 host Manchester United in the Champions League league phase, Matchday 3, at Giuseppe Sinigaglia in Como on Wednesday, October 21, 2026, kickoff 16:45 UTC (6:45 PM local (UTC+2)).

Chelsea host Manchester United in the Premier League at Stamford Bridge on Saturday, October 31, 2026, kickoff 15:00 UTC. ESPN's head-to-head shows United winning 2-1 at Stamford Bridge in 2025-26, while Chelsea won 2-0 at Old Trafford the same season.

Manchester United host AS Roma in the Champions League league phase, Matchday 4, at Old Trafford in Manchester on Tuesday, November 3, 2026, kickoff 20:00 UTC (8:00 PM local (UTC+0)).

Liverpool host Manchester United in the Premier League at Anfield on Saturday, November 21, 2026, kickoff 15:00 UTC. ESPN's head-to-head shows United winning both 2025-26 league meetings, 3-2 and 2-1, after Liverpool went unbeaten against them in 2024-25 with a 3-0 win and a 2-2 draw.

Sporting CP host Manchester United in the Champions League league phase, Matchday 5, at Estádio José Alvalade in Lisbon on Wednesday, November 25, 2026, kickoff 20:00 UTC (8:00 PM local (UTC+0)).

Manchester United host RB Leipzig in the Champions League league phase, Matchday 6, at Old Trafford in Manchester on Tuesday, December 8, 2026, kickoff 20:00 UTC (8:00 PM local (UTC+0)).

Manchester United host Newcastle United in the Premier League at Old Trafford on Wednesday, January 6, 2027, kickoff 20:00 UTC. ESPN's head-to-head shows Newcastle winning both 2025-26 league meetings, 2-1 and 1-0, after the sides split in 2024-25 with a 4-1 Newcastle win and a 2-0 United win.

Manchester United host Bayern Munich in the Champions League league phase, Matchday 7, at Old Trafford in Manchester on Wednesday, January 20, 2027, kickoff 20:00 UTC (8:00 PM local (UTC+0)).

Manchester United host Liverpool in the Premier League at Old Trafford on Saturday, January 23, 2027, kickoff 15:00 UTC. It is the return fixture to the sides' November 21 meeting at Anfield earlier in the season.

Villarreal host Manchester United in the Champions League league phase, Matchday 8, at Estadio de la Cerámica in Villarreal on Wednesday, January 27, 2027, kickoff 20:00 UTC (9:00 PM local (UTC+1)).

Manchester United host Chelsea in the Premier League at Old Trafford on Saturday, February 6, 2027, kickoff 15:00 UTC. It is the return fixture to the sides' October 31, 2026 meeting at Stamford Bridge.

Manchester United host Arsenal in the Premier League at Old Trafford on Saturday, February 27, 2027, kickoff 15:00 UTC.

Manchester City host Manchester United in the Premier League Manchester derby at the Etihad Stadium on Saturday, March 20, 2027, kickoff 15:00 UTC, the return leg of the September 13 derby at Old Trafford. ESPN's head-to-head shows United winning both 2025-26 league meetings, 2-0 and 3-0.

Manchester United host Crystal Palace in the Premier League at Old Trafford on Saturday, April 24, 2027, kickoff 14:00 UTC. ESPN's head-to-head shows the sides splitting the 2025-26 league meetings, each winning 2-1.

Tottenham Hotspur host Manchester United in the Premier League at Tottenham Hotspur Stadium in London on Sunday, May 23, 2027, kickoff 14:00 UTC. It is the last Manchester United fixture on the agenda for the 2026-27 season.